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Synovi G4® Soft Chews for dogs packaging.

Synovi G4® Soft Chews



Joint health, mobility and free radicals



Soft Chew

Active Ingredient

Active Ingredients:

Glucosamine HCI (shellfish), methylsulfonylmethane (MSM), creatine monohydrate, Boswellia serrata extract (containing 65% boswellic acids), Perna canaliculus (green-lipped mussel), proprietary blend of dicalcium phosphate, citrus bioflavonoids, ascorbic acid (vitamin C), manganese sulfate, grape seed extract, zinc sulfate and alpha lipoic acid, Curcuma longa (turmeric), selenium (as L-Selenomethionine), D-Alpha tocopheryl acetate (vitamin E)


Helping dogs maintain a healthy lifestyle is easy with Synovi G4®, a multimodal formulation to help support joint health and flexibility in dogs of all ages. With a formula based on the established Synovi® support matrix of joint health agents, Synovi G4® is upgraded with the added joint health and antioxidant benefits of Boswellia serrata and turmeric. 

Synovi G4® palatable soft chews can be used as a standalone product or in coordination with Free Form™ and/or Alenza® Soft Chews for additional supplemental support. Joint supplements are typically given to dogs as they start to age, slow down or experience difficulty climbing stairs. For active dogs, a joint supplement can also help maintain joint health and mobility.

CAUTIONS: Safe use in pregnant animals or animals intended for breeding has not been proven. If lameness  worsens, discontinue use and contact your veterinarian. Administer during or after the animal has eaten to reduce incidence of gastrointestinal upset. An examination from a veterinarian is recommended prior to using this product.

WARNING: For animal use only. Keep out of the reach of children and animals. In case of accidental overdose, contact a health professional immediately.


  • Joint health
  • Mobility
  • Free radicals


What are the active ingredients in Synovi G4®?

Synovi G4® soft chews help maintain joint health by combining a novel blend of antioxidants, glucosamine, creatine, MSM, turmeric and Boswellia serrata.

Per 7.2-gram soft chew:

  • 450 mg glucosamine HCI (shellfish) 
  • 400 mg methylsulfonylmethane (MSM)
  • 250 mg creatine monohydrate
  • 150 mg Boswellia serrata extract (containing 65% boswellic acids)
  • 150 mg Perna canaliculus (green-lipped mussel)
  • 148 mg proprietary blend of dicalcium phosphate, citrus bioflavonoids, ascorbic acid (vitamin C), manganese sulfate, grape seed extract, zinc sulfate and alpha lipoic acid
  • 50 mg Curcuma longa (turmeric)
  • 10 mcg selenium (as L-Selenomethionine)
  • 25 IU D-Alpha tocopheryl acetate (vitamin E)
How long will a 60-count, 120-count and 240-count tub of Synovi G4® last?

Assuming only one dog is receiving Synovi G4®, each bag/tub count will last according to the following:

5 to 15 lbs.
60 count — 8 months
120 count — 16 months
240 count — up to 24 months*

16 to 30 lbs.
60 count — 4 months
120 count — 8 months
240 count — 16 months

31 to 60 lbs.
60 count — 2 months
120 count — 4 months
240 count — 8 months

61 to 100 lbs.
60 count — 1 month
120 count — 2 months
240 count — 4 months

Over 100 lbs.
60 count — 24 days
120 count — 48 days
240 count — 3 months

*Please note the shelf life for Synovi G4® is 24 months.

What are the packaging specifications for Synovi G4® Soft Chews?

Synovi G4® Soft Chews 60 count
Synovi G4® Soft Chews 120 count
Synovi G4® Soft Chews 240 count

What is Boswellia serrata?

Boswellia serrata, also known as Indian frankincense, is a large branching tree native to India, North Africa and the Middle East. The tree’s resin contains boswellic acids, which have been shown in laboratory studies to support a healthy inflammatory response1 and promote joint health.2Boswellia serrata may also help with occasional discomfort and joint stiffness due to daily activity.3

1Safayhi H, Mack T, Sabieraj J, et al. (1992). J Pharmacol Exp Ther. 261(3):1143-1146.
2Reddy GK, Chandrakasan G, Dhar SC. (1989). Biochem Pharmacol. 38(20):3527-3534.
3Reichling J, Schmökel H, Fitzi J, et al. (2004). Schweiz Arch Tierheilkd. 146:71-79.

Product Label

Why use turmeric?

The active component of turmeric, curcumin, is a yellow phytochemical extracted from the plant’s roots that has shown to have many properties, including antioxidant and free radical scavenging abilities. There is also in vitro data supporting a healthy inflammatory response1 and glutathione production.2 Glutathione is an antioxidant necessary for many normal cellular functions. 

1Goel A, Kunnumakkara AB, Aggarwal BB. (2008). Biochem Pharmacol. 75(4):787-809.
2Dickinson DA, Iles KE, Zhang H, et al. (2003). FASEB Journal. 17(3):473-475.

Product Label

Why use antioxidants?

Antioxidants like those found in Synovi G4® support a dog’s health by battling free radicals throughout the body. Free radicals are formed when a normal atom loses an electron and becomes unstable. While free radicals are natural by-products of normal bodily functions, when produced in excess, they can cause cell damage throughout the body. This damage is commonly referred to as free radical oxidative stress. 

Some of the factors that can contribute to free radical formation and increase oxidative stress include air pollution, illness and inflammation, and excessive UV light exposure.1

Antioxidants play a vital role by neutralizing free radicals by contributing the missing electrons atoms need without becoming free radicals themselves. As a result, antioxidants can reduce free radicals, helping the body work naturally to reduce oxidative stress. Protecting the body from free radical oxidative stress can maintain a normal, healthy inflammatory response. 

1Rahman K. (2007). Studies on free radicals, antioxidants, and co-factors. Clinical Interventions in Aging. 2(2):219-236.

Product Label

Why does Synovi G4® not contain chondroitin?

Synovi G4® is based on the proven joint support matrix in Synovi G3®, which contains Perna canaliculus (also known as green-lipped mussel) found in the coastal waters of New Zealand. Perna is a rich source of chondroitin as well as omega-3 fatty acids.

Product Label

Why combine Boswellia and turmeric into one supplement?

These two ingredients were added because they are not commonly found in traditional joint supplements and are known for a variety of health benefits. A growing body of evidence indicates that both Boswellia and turmeric may be beneficial in the support of healthy joints, including cartilage and connective tissue, as well as a healthy inflammatory response.

Product Label

What can patients expect after giving Synovi G4® to their dog?

It varies depending on a wide scope of factors, such as lifestyle, genetic predispositions, body condition and type of discomfort. It is possible that pet owners may notice some benefit within two to four weeks.

How should Synovi G4® be stored?

Store at room temperature in a location a dog cannot access. Synovi G4® is provided in a bag/tub and should be kept sealed and stored at room temperature when not in use. It does not require refrigeration or any other special storage.

What is the protein source for Synovi G4® (flavor)?

The protein source is poultry liver.

Product Label

What is the National Animal Supplement Council (NASC) Quality Seal found on Synovi G4® and all Bayer supplements?

The Seal of Quality is a way for consumers to know the product they are buying comes from a reputable manufacturer that voluntarily complies with the standards set forth by the National Animal Supplement Council (NASC).  
The NASC is a nonprofit trade organization dedicated to protecting and enhancing the health of companion animals and horses throughout the United States.  Their mission is simple: To promote the health and well-being of non human food chain animals that are given animal health supplements, by establishing federal and state regulations that are fair, reasonable, responsible and nationally consistent.

Five factors for a NASC Quality Seal: proper label guidelines, comprehensive quality control and production procedures, product testing, ingredients reviewed by NASC’s committee, and monitoring of products.


When you see the Quality Seal on a product, you can trust it comes from a reputable company that has successfully passed an independent quality audit. 

Charts & Tables

What are the dosing and frequency guidelines for Synovi G4®? 

Synovi G4® can be given during or after mealtime. The recommended dosage is:

  Weight Number of Chews  
  5 to 15 lbs. ½ chew every other day  
  16 to 30 lbs. ½ chew daily  
  31 to 60 lbs. 1 chew daily  
  61 to 100 lbs. 2 chews daily  
  Over 100 lbs. 2 ½ chews daily  

Synovi G4®, Synovi G3®, Synovi ®, Alenza ® and Free FormTM are trademarks of Elanco or its affiliates.

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