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Baytril® Otic (enrofloxacin/silver sulfadiazine) Emulsion packaging and bottles with ear dropper tips.

Baytril® Otic (enrofloxacin/silver sulfadiazine) Antibacterial-Antimycotic Emulsion



Canine otitis externa



Bacteria and yeast




Active Ingredient

Active Ingredients:

Enrofloxacin, silver sulfadiazine


When you see Gram (-) rods, reach for Baytril® Otic. It is the only FDA-approved treatment with the powerful combination of silver sulfadiazine and enrofloxacin proven to stop Pseudomonas.

Baytril® Otic (enrofloxacin/silver sulfadiazine) Antibacterial-Antimycotic Emulsion is a topical, nonirritating, water-based emulsion that is easy to administer.

The product uniquely features two different antimicrobials with activity against difficult pathogens such as Pseudomonas.

Silver sulfadiazine (SSD) modifies and weakens cell membranes and walls, while enrofloxacin attacks DNA gyrase to interfere with bacterial DNA replication. SSD also provides activity against yeast.

CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

PRECAUTIONS: The safe use of Baytril® Otic in dogs with perforated tympanic membranes has not been evaluated. Therefore, the integrity of the tympanic membrane should be evaluated before administering this product. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of Baytril® Otic.

CONTRAINDICATIONS: Baytril® Otic is contraindicated in dogs with suspected or known hypersensitivity to quinolones and/or sulfonamides.


  • Canine otitis externa
  • Dermatology
  • Infections


What are the active ingredients in Baytril® Otic?

Each mL contains:

  • 5 mg enrofloxacin
  • 10 mg silver sulfadiazine (SSD)

- Silver sulfadiazine (SSD) attacks from the outside, weakening the cell wall and membrane, and is effective against Gram (+) cocci, Gram (-) rods and budding yeast.

- Enrofloxacin works from the inside, interfering with the DNA replication and destroying bacterial DNA, and is effective against Gram (+) cocci and Gram (-) rods.

2 active ingredients of Baytril® Otic - Enrofloxacin attacking on the inside and Silver Sulfadiazine attacking on the outside.

What is silver sulfadiazine (SSD)?

Silver sulfadiazine (SSD) is used to treat infections. It attacks on the outside of the infection by breaking down cell wall membranes. SSD is effective against Gram (+) cocci, Gram (-) rods and budding yeast.

Baytril® Otic is the ONLY FDA-approved otitis externa treatment that gives you the power of SSD, which is not found in any other OE ear product. The amount in Baytril® Otic is 1,000 times the amount needed to stop Pseudomonas.1*

Baytril® Otic delivers up to 1,000 times the minimum amount of silver sulfadiazine needed to stop tough Pseudomonas in vitro.

Do I need cytology before prescribing Baytril® Otic?

It is best practice to confirm Pseudomonas ear infections with cytology. A quick and inexpensive cytology test can find bacteria, yeast and inflammatory cells to determine rods, cocci and yeast organisms and can help you prescribe the best course of treatment.

Baytril® Otic is positioned to treat the toughest otitis externa cases (especially Pseudomonas/rod-shaped bacteria on cytology), which aren't as common or as frequent as Gram-positive bacteria and yeast.

What are the dosing and frequency guidelines for Baytril® Otic?

Shake well before each use. 

Tilt patient’s head so that the affected ear is presented in an upward orientation. Administer a sufficient quantity of Baytril® Otic to coat the aural lesions and the external auditory canal. As a general guide, administer 5 to 10 drops per treatment to dogs weighing 35 lbs. or less, and 10 to 15 drops per treatment in dogs weighing more than 35 lbs. Following treatment, gently massage the ear to ensure complete and uniform distribution of the medication throughout the external ear canal. After initial application, clients can apply twice daily for up to 14 days.

How is Baytril® Otic available?

Baytril® Otic can be purchased in multiples of 12: supplied as 15 mL bottles with dropper tip and extended tip closure, in boxes of 12 bottles each.

Product Label | MSDS

1 Silva-Tarouca M, Wolf G, Mueller R. (2019). Determination of minimum inhibitory concentrations for silver sulfadiazine and other topical antimicrobial agents against strains of Pseudomonas aeruginosa isolated from canine otitis externa. Vet Dermatol. 30:145-e42.

*The clinical significance of in vitro data has not been demonstrated.

©2020 Elanco or its affiliates. Baytril is sold by Elanco or its affiliates and is not a product of Bayer. Baytril is owned by Bayer and used under license. PM-US-20-2187

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