Advantage Multi® (imidacloprid + moxidectin) for Dogs and Cats

Indication:

Monthly broad-spectrum heartworm, intestinal parasite and flea protection

Spectrum:

In dogs: Heartworms, fleas, hookworms, roundworms, whipworms, sarcoptic mange, microfilaria
In cats: Fleas, ear mites, roundworms, hookworms, heartworms
In ferrets: Fleas, flea infestations, heartworms

Formulation:

Topical

Active Ingredients:

Imidacloprid, moxidectin

MSDS

Product Label

Description
Concerns
FAQs
Charts & Tables

Description

Advantage Multi^® (imidacloprid + moxidectin) provides broad-spectrum parasite protection in a convenient monthly topical application, potentially increasing compliance for dogs and cats that may not prefer oral medications.

For dogs, Advantage Multi^® prevents heartworm disease and treats heartworm microfilaria, kills fleas and treats and controls roundworms, hookworms, whipworms and sarcoptic mange. For cats, Advantage Multi^® kills fleas, treats and controls ear mites, roundworms and hookworms and prevents heartworm disease — all in one easy-to-use topical application. Plus, it’s the only FDA-approved product indicated for ferrets for the treatment of fleas and prevention of heartworm disease.

CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs: WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application, ensure that dogs cannot lick the product from application sites on themselves or other treated animals. (See Contraindications and Adverse Reactions for more information.)

Cats and ferrets: WARNING: Do not use on sick or debilitated cats or ferrets. Do not use on underweight cats. (See Contraindications and Adverse Reactions for more information.) Do not use on cats less than 9 weeks of age and cats or ferrets less than 2 lbs. body weight.

PRECAUTIONS: Avoid oral ingestion.

HUMAN WARNINGS: Children should not come in contact with application sites for 2 hours after application.

Concerns

Ear mites
Fleas
Heartworms
Heartworm microfilaria
Hookworms
Roundworms
Sarcoptic mange
Whipworms

FAQs

What are the active ingredients in Advantage Multi®?

10 mg/kg imidacloprid
2.5 mg/kg moxidectin for dogs; 1.0 mg/kg moxidectin for cats

Moxidectin is quickly absorbed through the skin into the subcutaneous fat and the bloodstream to prevent heartworm disease, treat and control internal parasites, treat sarcoptic mange in dogs and treat ear mites in cats. Imidacloprid spreads over the skin and coat to kill fleas through contact so they do not have to bite to die.

What are the dosing and frequency guidelines for Advantage Multi®?

As heartworm, fleas and internal parasites can be a threat year-round, we recommend the use of Advantage Multi^® monthly, year-round for your patients.

For dogs, the recommended minimum dose is 4.5 mg/lb. (10.0 mg/kg) imidacloprid and 1.1 mg/lb. (2.5 mg/kg) moxidectin once a month by topical administration. Administer the entire contents of the Advantage Multi^® for Dogs tube that correctly corresponds with the body weight of the dog.

For cats, the recommended minimum dose is 4.5 mg/lb. (10.0 mg/kg) imidacloprid and 0.45 mg/lb. (1.0 mg/kg) moxidectin once a month by topical administration. Administer the entire contents of the Advantage Multi^® for Cats tube that correctly corresponds with the body weight of the cat.

For ferrets, the recommended minimum dose is 9.0 mg/lb. (20.0 mg/kg) imidacloprid and 0.9 mg/lb. (2.0 mg/kg) moxidectin once a month by topical administration. Only the 0.4 mL applicator tube volume (Advantage Multi^® 9 for Cats) should be used on ferrets.

What are the packaging specifications for Advantage Multi®?

Advantage Multi^® 9 for Dogs
For dogs weighing 3-9 lbs.
1 card / 6 doses per card (0.4 mL tubes) — 08891454

Advantage Multi^® 20 for Dogs
For dogs weighing 9.1-20 lbs.
1 card / 6 doses per card (1.0 mL tubes) — 08891462

Advantage Multi^® 55 for Dogs
For dogs weighing 20.1-55 lbs.
1 card / 6 doses per card (2.5 mL tubes) — 08891470

Advantage Multi^® 88 for Dogs
For dogs weighing 55.1-88 lbs.
1 card / 6 doses per card (4.0 mL tubes) — 08891489

Advantage Multi^® 110 for Dogs
For dogs weighing 88.1-110 lbs.
1 card / 6 doses per card (5.0 mL tubes) — 80560290

Advantage Multi^® 5 for Cats
For cats weighing 2-5 lbs.
1 card / 3 doses per card (0.23 mL tubes) — 08890342

Advantage Multi^® 9 for Cats
For cats weighing 5.1-9 lbs. and ferrets weighing 2-4.4 lbs.
1 card / 6 doses per card (0.4 mL tubes) — 08891438

Advantage Multi^® 18 for Cats
For cats weighing 9.1-18 lbs.
1 card / 6 doses per card (0.8 mL tubes) — 08891446

Advantage Multi^® for Cats and Dogs does have an expiration date that can be found on the bottom edge of the package. Advantage Multi^® should not be used past its expiration date.

Does Advantage Multi® protect against heartworms even after your patient gets wet?

Yes. Studies have shown that swimming and bathing 60 and 90 minutes, respectively, after dosing does not affect the efficacy of heartworm protection in dogs.¹

¹Freedom of Information Summary Supplement, NADA: 141-251.

Some of my patients weigh more than the largest available size of Advantage Multi® for Dogs or Advantage Multi® for Cats. Can I still recommend Advantage Multi®?

Yes, you can still treat your patients with Advantage Multi® with the appropriate combination of tubes to meet the dog or cat’s proper weight specifications.

Is Advantage Multi® for Cats a suitable parasite protection for ferrets?

Yes, Advantage Multi^® 9 for Cats weighing 5.1-9 lbs. is the only FDA-approved product indicated for killing adult fleas, treating flea infestations and preventing heartworm disease in ferrets that weigh at least 2 lbs.

Charts & Tables

See for yourself how Advantage Multi^® for Dogs compares to other preventives.^†

			**
HEARTWORM		✓	✓	✓	✓	✓	✓	✓	✓
Microfilaria		✓	X	X	X	X	X	X	X
FLEAS		✓	X	✓	✓	✓	X	✓	X
SARCOPTIC MANGE		✓	X	X	X	X	X	✓	X
EAR MITES		X	X	X	X	X	X	✓	X
ROUNDWORMS	T. canis adults	✓	X	✓	✓	✓	✓	X	✓
	T. canis immature adults	X	X	✓	X	X	X	X	X
	T. canis L4	✓	X	X	X	X	X	X	X
	T. leonina	✓	X	✓	✓	✓	✓	X	✓
HOOKWORMS	A. caninum adults	✓	✓	✓	✓	✓	✓	X	✓
	A. caninum immature adults	✓	X	X	X	X	X	X	X
	A. caninum L4	✓	✓	X	X	X	X	X	X
	U. stenocephala adults	✓	✓	✓	X	X	X	X	Y
	U. stenocephala immature adults	✓	X	X	X	X	X	X	X
	U. stenocephala L4	✓	✓	X	X	X	X	X	X
	A. braziliense	X	X	X	X	X	X	X	✓
WHIPWORMS		✓	X	X	✓	✓	✓	X	X
TAPEWORMS		X	X	X	X	✓	✓	X	X
TICKS		X	X	✓	X	X	X	✓	X

^{^†Based on label comparisons.

**ProHeart® 6 and 12 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma canimum and Uncinaria stenocephala) infections.}

See for yourself how Advantage Multi^® for Cats compares to other preventives.^†


FLEAS		✓	✓	✓	X	X
HEARTWORM		✓	✓	✓	✓	✓
EAR MITES		✓	✓	X	X	X
ROUNDWORMS	T. cati adults	✓	✓	✓	✓	X
	T. cati immature adults	X	X	✓	X	X
	T. cati L4	✓	X	✓	X	X
HOOKWORMS	A. tubaeforme adults	✓	✓	✓	✓	✓
	A. tubaeforme immature adults	✓	X	✓	X	X
	A. tubaeforme L4	✓	X	✓	X	X
	A. braziliense adults	X	X	X	X	✓
	A. braziliense immature adults	X	X	X	X	✓
TICKS		X	✓	✓	X	X

^{^†Based on label comparisons.}

What are the dosing and frequency guidelines for Advantage Multi^®?

Dog (lbs.)	Advantage Multi^® for Dogs	Volume (mL)	Imidacloprid (mg)	Moxidectin (mg)
3-9	Advantage Multi^® 9	0.4	40	10
9.1-20	Advantage Multi^® 20	1.0	100	25
20.1-55	Advantage Multi^® 55	2.5	250	62.5
55.1-88	Advantage Multi^® 88	4.0	400	100
88.1-110*	Advantage Multi^® 110	5.0	500	125

^{*Dogs over 110 lbs. should be treated with the appropriate combination of Advantage Multi^® for Dogs tubes.}

Cat (lbs.)	Advantage Multi^®for Cats	Volume (mL)	Imidacloprid (mg)	Moxidectin (mg)
2-5	Advantage Multi^® 5	0.23	23	2.3
5.1-9	Advantage Multi^® 9	0.4	40	4
9.1-18*	Advantage Multi^®18	0.8	80	8

^{*Cats over 18 lbs. should be treated with the appropriate combination of Advantage Multi^® for Cats tubes.}

^{Advantage Multi is a registered trademark of Elanco or its affiliates.}

^{All other trademarks are the property of their respective owners.}

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