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Advantage® II (imidacloprid + pyriproxyfen) for Cats packaging.

Advantage® II for Cats



Flea prevention and infestation



Fleas, flea eggs and flea larvae




Active Ingredient

Active Ingredients:

Imidacloprid and pyriproxyfen

Advantage® II for Cats

Advantage® II is an easy-to-apply topical that kills fleas through contact so that they don't have to bite your pet to die. Advantage® II kills fleas rapidly — within 12 hours of initial application — and is waterproof after 24 hours. 

Advantage® II effectively treats existing flea infestations and prevents further infestations by killing adult fleas, flea larvae and flea eggs to break the flea life cycle. Reinfesting fleas are killed within 2 hours, and protection against further flea infestation lasts for up to a month. For use on cats and kittens 8 weeks of age and older, weighing 2 lbs. or more.

Side effects, although very rare, may include signs of skin irritation such as redness, scratching or other signs of discomfort. Gastrointestinal signs such as hypersalivation, vomiting or diarrhea have also been reported. Individual sensitivities, while rare, may occur after using ANY pesticide product for cats.

RESTRICTIONS: Use only on cats or kittens 8 weeks and older. Do not apply to cats or kittens weighing less than 2 lbs. Do not use on other animals. Do not apply more than 1 tube per treatment, even for large cats. 

Hazards to humans: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Keep out of reach of children; do not have contact or allow children to have contact with treated area until completely dry. Do not contaminate feed or food. 


  • Fleas
  • Flea eggs
  • Flea larvae
  • Flea infestations
  • Flea allergy dermatitis


What are the active ingredients in Advantage® II for Cats?
  • 9.10% imidacloprid
  • 0.46% pyriproxyfen

Imidacloprid attacks the flea's nervous system — paralyzing and ultimately killing it. Pyriproxyfen is an insect growth regulator (IGR) that mimics the juvenile growth hormone of fleas; this prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas. It also offers additional larvicidal properties when compared with imidacloprid alone. 

What are the dosing and frequency guidelines for Advantage® II for Cats?

Advantage® II for Cats can be applied monthly, year-round to keep your patients protected from fleas. A single application of Advantage® II for Cats stops biting fleas for one month. 

However, if the cat has a severe infestation, re-treatment within a month may be necessary. Do not re-treat more often than once every 14 days for kittens or once every 7 days for small and large cats; after flea control is attained, your client can return to a monthly re-treatment schedule.

What are the packaging specifications for Advantage® II for Cats?

Advantage® II is available in three weight bands:
Advantage® II Kitten, 2-5 lbs.
1 Sleeve of 12 2-Packs (0.23 mL tubes)
Advantage® II Small Cat, 5-9 lbs.
1 Sleeve of 12 4-Packs (0.4 mL tubes)
1 Sleeve of 12 6-Packs (0.4 mL tubes)
Advantage® II Large Cat, over 9 lbs.
1 Sleeve of 12 4-Packs (0.8 mL tubes)
1 Sleeve of 12 6-Packs (0.8 mL tubes)

There is no expiration date required on the packaging by the EPA for Advantage® II for Cats. We recommend the product should be kept in its original packaging and stored as directed on the label.

Why is it important to use a product with an IGR like Advantage® II for Cats?

With an IGR (insect growth regulator) as part of your practice’s flea control plan, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage® II provides ovicidal properties, as well as additional larvicidal properties, to target flea infestations and kill flea life stages.

Advantage is a registered trademark of Elanco or its affiliates.

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