Advantage Multi® is making it easier to help educate your clients on the value of multilayered heartworm, flea and IP protection.
Experience the Many Layers of Advantage Multi® (imidacloprid + moxidectin)
Why Choose Advantage Multi®
Heartworm disease prevention that works all month long
Kills fleas through contact so they don’t have to bite to die
Treats and controls roundworms, hookworms and whipworms in dogs and roundworms and hookworms in cats for deep, broad-spectrum coverage
The Power of a Transdermal Solution
Even pets who don’t love oral medication get the protection they need, as moxidectin is quickly absorbed through the skin while imidacloprid spreads over the skin and coat. But the benefits don’t stop there.
Heartworm prevention that works all month long
Like all heartworm prevention products, Advantage Multi® works backward to clear tissue stages of heartworms acquired during the previous month. It also works forward§ by killing newly acquired heartworm larvae all day, every day, all month long.1,2 This prevents the establishment of a heartworm infection because newly deposited larvae don’t grow or migrate in the dog between doses.
Kill Multiple Worms at Multiple Stages
Most products only cover adult worms.* Advantage Multi® delivers broad-spectrum intestinal parasite coverage to protect pets from multiple life stages of the most common intestinal parasites.
Advantage Multi® for Dogs
|Dogs||Advantage Multi®||ProHeart® 6/12**||Simparica Trio™||Trifexis®||Sentinel® Spectrum||Interceptor® Plus||Revolution®||Heartgard® Plus|
|T. canis adults||YES||NO||YES||YES||YES||YES||NO||YES|
|T. canis immature adults||NO||NO||YES||NO||NO||NO||NO||NO|
|T. canis L4||YES||NO||NO||NO||NO||NO||NO||NO|
|A. caninum adults||YES||YES||YES||YES||YES||YES||NO||YES|
|A. caninum immature adults||YES||NO||NO||NO||NO||NO||NO||NO|
|A. caninum L4||YES||YES||NO||NO||NO||NO||NO||NO|
|U. stenocephala adults||YES||YES||YES||NO||NO||NO||NO||YES|
|U. stenocephala immature adults||YES||NO||NO||NO||NO||NO||NO||NO|
|U. stenocephala L4||YES||YES||NO||NO||NO||NO||NO||NO|
*Based on label comparisons for intestinal parasites.
**ProHeart® 6 and ProHeart® 12 are indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Unciaria stenocephala) infections.
Advantage Multi® for Cats*
|Revolution® Plus||Bravecto® Plus||Interceptor®||Heartgard®|
|T. cati adults||YES||YES||YES||YES||NO|
|T. cati immature adults||NO||NO||YES||NO||NO|
|T. cati L4||YES||NO||YES||NO||NO|
|A. tubaeforme adults||YES||YES||YES||YES||YES|
|A. tubaeforme immature adults||YES||NO||YES||NO||NO|
|A. tubaeforme L4||YES||NO||YES||NO||NO|
|A. braziliense adults||NO||NO||NO||NO||YES|
|A. braziliense immmature adults||NO||NO||NO||NO||YES|
*Based on label comparisons for intestinal parasites.
More about Advantage Multi®
When Advantage Multi® is applied, imidacloprid spreads across the skin and coat and works through contact. It targets the nicotinic acetylcholine receptors on fleas, paralyzing and killing these nasty parasites — no biting necessary. This is unlike oral preventives, which work through the bloodstream, requiring fleas to bite and blood feed before dying.
When applied transdermally, moxidectin concentrates in the fatty tissue, slowly releasing into the bloodstream, resulting in a long half-life.
Help Your Clients See the Beauty of Multilayered Protection
Stock Advantage Multi®
§Forward protection from heartworm infection means that after a single dose of Advantage Multi®, blood levels of moxidectin are continuously at or above the concentration required to kill newly acquired heartworm larvae and are maintained between continued monthly administration of these products.
1Bowman DD, Ohmes CM, Hostetler JA, et al. (2017). Efficacy of 10% imidacloprid + 2.5% moxidectin topical solution (Advantage Multi® for Dogs) for the prevention of heartworm disease and infection all month long. Parasit Vectors. 10(2):59-64.
2Bowman DD, Ohmes CM, Bradford M, et al. (2018). Efficacy of Advantage Multi® for Cats for the prevention of heartworm disease and infection all month long. In: Proceedings. American Association of Veterinary Parasitologists. 63rd Annual Meeting. July 14-17, 2018. Denver, CO.
3Kojima K, Yamamoto K, Katae H, et al. (1987). Bioavailability of oral ivermectin in dogs. Jpn J Vet Sci. 49(5):899-900.
4SENTINEL® Spectrum [Summary of Product Characteristics]. Frimley, Camberley, Surrey, UK: Novartis Animal Health UK Ltd.; May 2008 revision.
5Sarasola P, Jernigan AD, Walker DK, et al. (2002). Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs. J Vet Pharmacol Therap. 25(4): 265-272.
6Data on file. Bayer, Shawnee Mission, KS.
7Kvaternick V, Kellermann M, Knaus M, et al. (2014). Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel. Vet Parasitol. 202:2-9.
CAUTION: Advantage Multi® is only available from a licensed veterinarian. Dogs: WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application, ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings and Adverse Reactions for more information.) Cats: Do not use on sick, debilitated, or underweight cats. Avoid oral ingestion.
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